Prognosis following seizures after successful cardiopulmonary resuscitation in a tertiary hospital: A retrospective cohort study.
- Author:
Liz Edenberg Quiles
1
;
Marc Laurence Fernandez
2
Author Information
- Publication Type:Journal Article
- Keywords: post-arrest seizures; anoxic brain injury; post-arrest myoclonus;
- MeSH: Prognosis
- From: Philippine Journal of Neurology 2021;24(1):24-32
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND:Neurologic outcomes following a cardiac arrest is reported to be detrimental and survivors face
significant neurologic disability attributed to the diffuse cerebral damage from anoxia. Accurate
prognostication is challenging.
OBJECTIVE:To determine the prognosis of patients who had seizures after arrest.
METHODS:This is an analytic, retrospective cohort study of adult patients that had successful resuscitation after cardiac arrest. The final sample size was 97. Comparison of the clinical outcomes was done using univariate and multivariate analysis. Multiple logistic regression was utilized. Level of significance was set at α-0.05.
RESULTS:Post-arrest seizures increased the odds of dying up to 9 times. Age increases the odds of dying; among patients aged 65 years old and above, the odds are increased to 17 times, while among those aged 35 years old and above, the odds are up to 12 times. Presence of an intact brainstem response in the first 72 hours after arrest have 96% lower odds of dying compared to those who have none.
CONCLUSION:Patients with post-arrest seizures have higher morbidity and mortality rates. Patients with seizures that occur early after cardiac arrest have poorer prognosis and higher chances of death brought about by additional insults to an already damaged brain. Older patients have poorer prognosis. Preserved brainstem function seem to be a protective factor which can be a reflection of the degree of preserved brain activity despite anoxia. - Full text:Prognosis following seizures.pdf
