Research progress on protective effect of hydrogen molecule and its products on lung transplantation
10.3969/j.issn.1674-7445.2023.02.018
- VernacularTitle:氢分子及其制品对肺移植保护作用的研究进展
- Author:
Menggen LIU
1
;
Peizhi LIU
;
Hongtao TANG
;
Heng HUANG
;
Dong TIAN
Author Information
1. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
Lung transplantation;
Hydrogen molecule;
Hydrogen-rich solution;
Ischemia-reperfusion injury;
Warm ischemia time;
Cold ischemia time;
Ex vivo lung perfusion;
Primary graft dysfunction
- From:
Organ Transplantation
2023;14(2):300-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury after lung transplantation is the main cause of primary graft dysfunction, which will subsequently reduce the function of lung allograft and lower the overall survival rate of lung transplant recipients. As a physiological regulatory molecule, hydrogen molecule has the functions of anti-inflammation, easing oxidative stress, alleviating direct cell injury and mitigating epithelial edema. Recent studies have demonstrated that hydrogen molecule and its products (hydrogen and hydrogen-rich solution) could significantly mitigate ischemia-reperfusion injury and postoperative complications after lung transplantation. In this article, the protective effect and exact mechanism of hydrogen molecule and its products in lung transplantation were reviewed, aiming to provide theoretical basis for the application of hydrogen molecule and its products as a novel treatment for lung transplantation-related complications, enhance the overall prognosis and improve the quality of life of lung transplant recipients
