Research status and progress on limb preservation technology
10.3969/j.issn.1674-7445.2023.02.017
- VernacularTitle:肢体保存技术的研究现状及进展
- Author:
Yuhong LI
1
;
Wenyu ZHAO
;
Li ZENG
Author Information
1. Department of Organ Transplantation, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
Limb replantation;
Limb transplantation;
Limb preservation;
Vascularized composite tissue allotransplantation;
Static cold storage;
Ultra-low temperature preservation;
Supercooling preservation;
Mechanical perfusion
- From:
Organ Transplantation
2023;14(2):295-
- CountryChina
- Language:Chinese
-
Abstract:
Limb replantation and transplantation is the optimal treatment for traumatic limb amputation. Safe and effective limb preservation is the key factor to determine the success of limb replantation and transplantation. Currently, static cold storage is the gold standard of limb preservation. However, the preservation time is short, which may no longer meet clinical requirements. With rapid development of organ preservation in recent years, novel preservation technologies, such as ultra-low temperature preservation, supercooling preservation and mechanical perfusion preservation, have successively emerged. However, at present, these techniques are primarily applied to the preservation of solid organs rather than composite tissue allografts with blood vessels including limbs. In this article, research status and progress on the application of static cold storage and mechanical perfusion preservation in limb preservation were reviewed, aiming to provide reference for clinical application of limb preservation technology and promote the development of limb replantation and transplantation.
