Status of clinical research in HCV-negative recipients undergoing kidney transplantation from HCV-positive renal allografts
10.3969/j.issn.1674-7445.2023.02.009
- VernacularTitle:HCV阴性受者接受HCV阳性供肾肾移植临床研究现状
- Author:
Maozhi TANG
1
;
Keqin ZHANG
Author Information
1. Urinary Nephropathy Center, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
- Publication Type:Research Article
- Keywords:
Hepatitis C virus (HCV);
Kidney transplantation;
Direct antiviral agent (DAA);
Pegylated interferon;
Ribavirin;
Sustained virological response;
Estimated glomerular filtration rate;
Delayed graft function
- From:
Organ Transplantation
2023;14(2):235-
- CountryChina
- Language:Chinese
-
Abstract:
Antiviral therapy for chronic hepatitis C virus (HCV) infection has entered the era of direct antiviral agent (DAA), and up to 95% of patients could be clinically cured. Under this circumstance, HCV infection has gradually changed from relative contraindication to surgical indication for kidney transplantation. However, at present, the number of kidney transplantation from HCV-infected donors or recipients has been rarely reported in China. The short-term follow-up data of HCV-negative recipients undergoing kidney transplantation from HCV-positive renal allografts in other countries have confirmed that DAA yields high cure rate and safety in the treatment of HCV infection, and recipients could obtain favorable short-term survival and allograft outcome. However, the long-term safety of HCV-infected kidney transplantation remains to be validated by clinical trials with large sample size and long-term follow-up. In this article, the virological clearance, allograft outcome and safety of DAA use in HCV-negative recipients undergoing kidney transplantation from HCV-positive renal allografts under the intervention of DAA were investigated, aiming to evaluate clinical safety and efficacy of this pattern of kidney transplantation and deepen the understanding of safe use of HCV-positive organs.