The past, present and future of heart transplantation
10.3969/j.issn.1674-7445.2023.02.008
- VernacularTitle:心脏移植的过去、现在和未来
- Author:
Zihe ZHENG
1
;
Zheng XU
;
Xinfan LIN
;
Tao WANG
;
Wei WANG
;
Xin JIANG
;
Xiaofu DAI
Author Information
1. Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China
- Publication Type:Research Article
- Keywords:
End-stage heart failure;
Heart allotransplantation;
Organ shortage;
Marginal donor heart;
Artificial heart;
Heart xenotransplantation;
Gene editing;
Cardiac organoid
- From:
Organ Transplantation
2023;14(2):227-
- CountryChina
- Language:Chinese
-
Abstract:
Heart transplantation is one of the most effective strategies to treat end-stage heart failure. Multiple challenges, such as difficulty in preservation of heart allograft, rejection and postoperative complications, emerge in heart allotransplantation. After decades of research and practice, most problems have been resolved. Nevertheless, the shortage of donor organs has become increasingly prominent. To alleviate the shortage of donor organs, artificial heart and heart xenotransplantation have captivated attention, and obtained significant progress in recent years. The application of artificial heart in clinical practice has significantly enhanced the survival rate of patients with end-stage heart failure, which is expected to become the standard treatment for end-stage heart failure. Heart xenotransplantation still faces many challenges, which is still far from clinical application. In this article, the history of heart transplantation, development of heart allotransplantation, use of artificial heart and research progress on heart xenotransplantation were reviewed, and the future development direction of heart transplantation was predicted.
