Preservation and functional maintenance of lung allograft
10.3969/j.issn.1674-7445.2023.02.006
- VernacularTitle:移植供肺的保存与功能维护
- Author:
Chunxiao HU
1
;
Jingbo SHAO
;
Jin ZHAO
;
Jingyu CHEN
Author Information
1. The Affiliated Wuxi People's Hospital of Nanjing Medical University, Jiangsu Lung Transplant Center, Wuxi Lung Transplant Center, Wuxi 214023, China
- Publication Type:Research Article
- Keywords:
Lung transplantation;
Donor lung preservation;
Functional maintenance;
Primary graft dysfunction;
Ex vivo lung perfusion;
Mechanical ventilation;
Fluid management;
Hormone
- From:
Organ Transplantation
2023;14(2):213-
- CountryChina
- Language:Chinese
-
Abstract:
As the final resolution for end-stage lung disease, lung transplantation can not only significantly prolong the survival, but also remarkably improve the quality of life of recipients. In recent decades, with the advancement of surgical techniques, immunosuppressants and post-transplantation management, the quantity of lung transplantation has been surged around the globe. However, the shortage of donor lung has severely restricted the development of lung transplantation. It is necessary to develop innovative approaches to expand the donor pool. The number of donors and effective preservation and functional maintenance of potential donor lungs play a key role in expanding the donor pool. The quality of donor lung is a critical precondition to ensure the long-term survival of lung transplant recipients. Preservation and functional maintenance of donor lung are of significance for guaranteeing the quality of lung allograft. In this article, research progresses on the management and maintenance of donor lung before procurement, the procurement of donor lung and the preservation and functional maintenance of lung allograft were reviewed, aiming to provide reference for the development of lung transplantation in clinical practice.
