Research progress on islet protection and functional maintenance
10.3969/j.issn.1674-7445.2023.02.005
- VernacularTitle:胰岛保护和功能维护的研究进展
- Author:
Hongjun GAO
1
;
Minhua QIU
;
Jibing CHEN
Author Information
1. Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi Clinical Medical Research Center for Renal Diseases of Integrated Chinese and Western Medicine, Nanning 530011, China
- Publication Type:Research Article
- Keywords:
Islet transplantation;
Islet protection;
Diabetes mellitus;
Stem cell;
Exosome;
Instant blood-mediated inflammatory reaction (IBMIR);
B cell-lymphoma-2 associated X protein (Bax);
Cysteinyl aspartate specific proteinase (Caspase)
- From:
Organ Transplantation
2023;14(2):207-
- CountryChina
- Language:Chinese
-
Abstract:
Islet transplantation is a promising treatment of diabetes mellitus and its complications. Nevertheless, dysfunction post-transplantation, rejection and shortage of donors are the bottleneck issues in the field of islet transplantation. Optimizing the preservation method of pancreas plays a positive role in obtaining a sufficient quantity of effective islets and maintaining their functions. During the culture stage, anti-rejection and anti-apoptosis treatment of islets, including mesenchymal stem cell (MSC), MSC-derived exosomes, anti-apoptosis drugs and gene modification, may become major approaches for islet protection and functional maintenance in clinical islet transplantation. Use of anti-instant blood-mediated inflammatory reaction (IBMIR) drugs after islet transplantation also plays a critical role in protecting islet function. In this article, the whole process from islet preparation to islet transplantation was illustrated, and relevant strategies of islet protection and functional maintenance were reviewed, aiming to provide reference for improving the quality of donors to compensate for the shortage of absolute quantity of donors and elevating the efficiency of islet transplantation.
