Effect of APA Microencapsulized Bovine Chromaffin Cells Transplantation on Endogenous Opioid Peptides and Catecholamine Concentration in CSF of Cancer Pain Patients
- VernacularTitle:蛛网膜下腔植入APA-BCC微胶囊对癌痛患者脑脊液中镇痛相关物质含量的影响
- Author:
Shuilong GUO
;
Jingkun PAN
;
Yuhong GAO
;
Xin CUI
;
Yun LUO
;
Lei TIAN
;
Yilong XUE
- Publication Type:Journal Article
- Keywords:
tranplantation, ease pain, chromaffin cell
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(2):164-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of APA-BCC(alginate-polylysine-alginate microencapsulated bovine adrenal medullary chromaffin cells)microcapsules transplantation into the subarachnoid space of cancer pain patients on endogenous opioid peptides and catecholamine concentration in cerebrospinal fluid(CSF).Methods The different doses of APA-BCC microcapsules were transplanted into the spinal subarachnoid space of cancer patients with moderate or serious pain.The concentrations of Leu-enkephalin(L-EK),β-endorphin(β-EP),dynorphin A(DynA),noradrenaline(NA)and adrenaline(AD)in CSF were tested.Results L-EK concentration in CSF increased remarkably after transplantation,and the increase was most remarkable when transplantation doses were 1.0×107and 1.25×107;there were no remarkable changes of β-EP,DynA,NA and AD after transplantation.Conclusion The analgetic effects of APA-BCC microcapsules tranplantation may correlate with the increase of L-EK in CSF of cancer pain patients;the dose of 1.0×107 and 1.25×107cells may be the most effective dose.
