Pharmacological Activities， Pharmacokinetics， and Adverse Reactions of Polyphyllin Ⅱ： A Review
10.13422/j.cnki.syfjx.20221825
- VernacularTitle:重楼皂苷Ⅱ的药理作用、药代动力学及不良反应研究进展
- Author:
Huating HUANG
1
;
Linyue PENG-HU
1
;
Manting LIU
1
;
Panxiang HU
1
;
Rongyue ZHU
1
;
Yuchang YANG
1
;
Changhai QU
1
;
Jian NI
1
;
Xiaoxu DONG
1
Author Information
1. School of Chinese Material Medica， Beijing University of Chinese Medicine， Beijing 102488， China
- Publication Type:Journal Article
- Keywords:
polyphyllin Ⅱ;
pharmacological activities;
pharmacokinetics;
adverse reactions;
anti-tumor effect
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(8):257-265
- CountryChina
- Language:Chinese
-
Abstract:
As a rare Chinese medicinal material， Paridis Rhizoma is mainly distributed in Yunnan， Guangxi， and Guizhou in southwestern China， with the effect of clearing heat and detoxifying， alleviating edema and relieving pain， cooling liver and tranquilizing mind. It is particularly effective for injuries from falls， fractures， contusions and strains， snake bites， cold wind-induced convulsion， and other diseases， which has been used for more than 2 000 years. According to modern research， polyphyllin Ⅱ， one of the main active components of Paridis Rhizoma， belongs to diosgenin in structure. It has the anti-tumor， anti-inflammatory， antiviral， antibacterial， immune-regulating， antioxidant， and multidrug resistance-reversing activities， showing good application prospect. Especially， the anti-tumor effect of polyphyllin Ⅱ has attracted wide attention， and the mechanism is inhibiting proliferation， migration， and invasion of tumor cells， inducing cell cycle arrest， apoptosis， and autophagy， suppressing angiogenesis， and modulating tumor microenvironment. However， the pharmacokinetic results show that polyphyllin Ⅱ has low bioavailability in vivo due to the low solubility， poor absorption， unsatisfactory distribution， and slow metabolism， which limit the clinical application. In recent years， there has been an explosion of research on the adverse reactions of polyphyllin Ⅱ， such as the strong hemolytic activity and obvious cytotoxicity to liver， kidney， myocardium and cardiovascular cells. Thus， papers were retrieved from "CNKI"， "VIP"， "Wanfang Data"， "PubMed"， "Web of Science"， and "Elsevier SD" with "Paris saponin Ⅱ"， "Polyphyllin Ⅱ" as the main keywords， and the pharmacological activities and mechanisms， pharmacokinetics， and adverse reactions were summarized. The findings are expected to serve as a reference for the in-depth research， development， and utilization of polyphyllin Ⅱ.
