Role of tumor-associated macrophages in cholangiocarcinoma
10.3969/j.issn.1001-5256.2023.02.035
- VernacularTitle:肿瘤相关巨噬细胞在胆管细胞癌中的作用
- Author:
Pinsheng HAN
1
;
Long YANG
2
;
Tao CUI
3
,
4
;
Yamin ZHANG
2
Author Information
1. Clinical Medical College of Tianjin Medical University, Tianjin 300070, China
2. Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300192, China
3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300000, China
4. Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing 100730, China
- Publication Type:Review
- Keywords:
Bile Duct Neoplasms;
Macrophages;
Tumor Microenvironment
- From:
Journal of Clinical Hepatology
2023;39(2):469-473
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma (CCA) is a highly malignant biliary tumor with strong invasion and poor prognosis and is insensitive to radiotherapy and chemotherapy. Tumor-associated macrophage (TAM) is an important component of the tumor microenvironment. CCA cells recruit TAM into tumor tissue by releasing cytokines and polarize them into M2 TAM, which promotes the progression of CCA through various mechanisms such as assisting immune escape, promoting tumor cell proliferation, regulating angiogenesis, promoting tumor metastasis, and mediating immune resistance. As an emerging target of tumor immunotherapy, TAM provides new ideas for targeted therapy for CCA. This article reviews the mechanisms of TAM in promoting the progression of CCA and immunotherapy targeting TAM in recent years.
