Biological connotation of

Fangming Yang; Zhun Xiao; Xiaoqi Chen; Chuanlei Zhang; Xinju Chen; Suping MA; Wenxia Zhao

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Biological connotation of "phlegm-turbidity" theory in hepatocellular carcinoma microenvironment based on abnormal lipid metabolism

VernacularTitle:基于脂质代谢异常探讨“痰浊”理论在肝细胞癌微环境中的生物学内涵
Author: Fangming YANG ¹ ; Zhun XIAO ¹ ; Xiaoqi CHEN ¹ ; Chuanlei ZHANG ¹ ; Xinju CHEN ¹ ; Suping MA ¹ ; Wenxia ZHAO ^{1
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Author Information

1. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
2. Henan University of Chinese Medicine, Zhengzhou 450000, China
Publication Type:Review
Keywords: Carcinoma, Hepatocellular; Lipid Metabolism; Phlegm Turbidity; Medicine, Chinese Traditional
From: Journal of Clinical Hepatology 2023;39(2):432-438
CountryChina
Language:Chinese
Abstract: There is still a lack of effective strategies for the prevention and treatment of liver cancer, and a deep understanding of its pathogenesis may help to develop new treatment methods. Due to the abnormal changes of lipid metabolism in the development and progression of liver cancer, such process is closely associated with the "phlegm-turbidity" theory in traditional Chinese medicine (TCM). Starting from the changes of lipid metabolism in hepatocellular carcinoma microenvironment, this article discusses the association of the abnormal changes of lipid metabolism in tumor cells and immune cells with the "phlegm-turbidity" theory and the clinical efficacy of phlegm-eliminating therapies in clinical practice. Since the "phlegm-turbidity" theory in TCM plays an important role in the pathogenesis and pathological changes of liver cancer, the analysis of its theoretical connotation helps to clarify pathological mechanism, thereby providing a theoretical basis for the role of TCM in the prevention and treatment of liver cancer.