Association between liver sinusoidal endothelial cells and liver fibrosis
10.3969/j.issn.1001-5256.2023.02.027
- VernacularTitle:肝窦内皮细胞与肝纤维化的关系
- Author:
Weiming DAI
1
;
Lungen LU
1
;
Xiaobo CAI
1
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
- Publication Type:Review
- Keywords:
Liver Cirrhosis;
Liver Sinusoidal Endothelial Cells;
Hepatic Stellate Cells
- From:
Journal of Clinical Hepatology
2023;39(2):419-423
- CountryChina
- Language:Chinese
-
Abstract:
Liver sinusoidal endothelial cells (LSECs) are crucial to the maintenance of hepatic homeostasis under physiologic conditions, while under the conditions of pathological liver damage, LSEC can respond to the damage by changing their structure through the process called capillarization, thereby aggravating liver damage. In addition, the interaction between LSEC and other cells in the liver plays a certain role in the development and progression of liver fibrosis, especially the interaction between LSEC and hepatic stellate cells, which are the primary effector cells of liver fibrosis. This article mainly elaborates on the role of LSEC in the development and progression of liver fibrosis during chronic liver injury.
