Association between liver fibrosis and gut microbiota based on "harmonizing liver and spleen"
10.3969/j.issn.1001-5256.2023.02.005
- VernacularTitle:基于“调和肝脾”论述肝纤维化与肠道菌群的关系
- Author:
Yunxiao LIU
1
;
Jing DOU
1
;
Xiaozhong WANG
2
Author Information
1. Fourth Clinical Medical College of Xinjiang Medical University, Urumqi 830000, China
2. Department of Hepatology, Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830000, China
- Publication Type:Discussions by Experts
- Keywords:
Liver Fibrosis;
Gastrointestinal Microbiome;
Harmonizing Liver and Spleen
- From:
Journal of Clinical Hepatology
2023;39(2):278-283
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is the leading cause of the morbidity and mortality of liver diseases worldwide and has become one of the key issues in the research on chronic liver diseases among domestic and foreign scholars. An increasing amount of evidence has shown that gut microbiota dysbiosis plays a crucial role in the development and progression of liver fibrosis, and improvement of gut microbiota dysbiosis has become a new target for anti-fibrotic treatment. At present, traditional Chinese medicine has attracted much attention in improving gut microbiota. Studies have shown that "harmonizing liver and spleen" plays an important role in reducing fibrosis degree and delaying the progression of liver fibrosis. Therefore, based on the theory of "harmonizing liver and spleen", the achievements in liver-gut axis and gut microbiota by modern molecular biological techniques can provide a theoretical basis for the treatment of liver fibrosis from "harmonizing liver and spleen" in clinical practice, as well as new directions and ideas for anti-fibrotic treatment with traditional Chinese medicine.
