Research progress on pharmacological effects of bilirubin nanoparticles
- VernacularTitle:胆红素纳米颗粒的药理作用研究进展
- Author:
Tingting QIAO
1
;
Zhihong ZHANG
2
;
Junfa ZHOU
1
;
Shigao YE
1
;
Yuanning ZENG
1
;
Qiuhong WANG
1
Author Information
1. Technical Research Center for Standardized Processing of Chinese Herbal Medicine Decoction Pieces，School of Traditional Chinese Medicine，Guangdong Pharmaceutical University，Guangzhou 510006，China
2. Key Laboratory of Basic and Application Research of Beiyao，Ministry of Education，Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
bilirubin;
nanoparticles;
anti-inflammatory;
anti-oxidation;
immune regulation;
anti-tumor;
targeted therapy
- From:
China Pharmacy
2023;34(5):631-635
- CountryChina
- Language:Chinese
-
Abstract:
Bilirubin has good anti-inflammatory， antioxidant and immunomodulatory effects， but its poor water solubility and low bioavailability greatly limit its clinical application. Researchers have developed bilirubin into various nanoparticles， which effectively eliminate the limitation of low solubility of bilirubin with the advantage of dosage form， so that they can maximize its pharmacological activities such as anti-inflammatory， anti-oxidation and immune regulation. Bilirubin nanoparticles have great application potential in a variety of gastrointestinal diseases， liver and kidney diseases， skin diseases， autoimmune diseases， islet transplantation and targeted therapy of tumors （both as a direct anti-tumor drug and as a drug delivery system）. The study of bilirubin nanoparticles will promote the clinical application of bilirubin and the development of related new drugs.
