Research progress on signal pathways related to prevention and treatment of hypertension target organ damage by traditional Chinese medicine
- VernacularTitle:中药防治高血压靶器官损害相关信号通路的研究进展
- Author:
Jiatan ZHOU
1
;
Jianqi LU
2
;
Wenkuan LUO
1
;
Min YANG
1
Author Information
1. Graduate School，Guangxi University of Chinese Medicine，Nanning 530001，China
2. Dept. of Cardiology/Branch of National Clinical Medical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
hypertension;
target organ damage;
signal pathway
- From:
China Pharmacy
2023;34(5):625-630
- CountryChina
- Language:Chinese
-
Abstract:
Hypertension is a common cardiovascular disease. At present， the prevalence and mortality of hypertension in China continue to rise， the morbidity and mortality of complications remain high. The continuous increase of blood pressure can cause damage to multiple target organs such as heart， brain， kidney and blood vessels. This article reviews the research progress of signal pathways related to the prevention and treatment of hypertension target organ damage by traditional Chinese medicine， and summarizes six signal pathways related to RhoA/ROCK， renin-angiotensin-aldosterone system， endothelin-1/nitric oxide， transforming growth factor-β1/Smads， phosphatidylinositide 3-kinases/protein kinase B， and Toll-like receptor 4/nuclear transcription factor-κB， in order to provide theoretical evidence for further research on clinical diagnosis and treatment of hypertension and its target organ damage.
