Morroniside Inhibits Hydrogen Peroxide-induced Apoptosis in SH-SY5Y Neuroblastoma Cells
- VernacularTitle:莫诺苷抑制过氧化氢诱导的SH-SY5Y神经细胞凋亡
- Author:
Wen WANG
;
Fanglng SUN
;
Yi AN
;
Houxi AI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
morroniside, SH-SY5Y neuroblastoma cell, lipid peroxidation, mitochondrial membrane potentials, apoptosis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(5):428-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of morroniside on hydrogen peroxide (H2O2)-induced apoptosis in SH-SY5Y neuroblastoma cells. Methods SH-SY5Y cells were pre-incubated with morroniside (1, 10, and 100 μmol/L) for 24 h prior to exposure to H2O2 (300～500 μmol/L) for 18 h. The content of malondialdehyde (MDA)，mitochondrial membrane potentials (MMP) and apoptosis ratio were determined. Results Pretreatment the cells with morroniside (1, 10 and 100 μmol/L) lowered the H2O2-induced MDA concentration and MMP, and inhibited the apoptosis. Conclusion Morroniside may protect the neurocyte from H2O2-induced apoptosis by lowered MDA and inhibits MMP.
