Advance in Apoptosis Mechanism on Nerve Cell after Cerebral Ischemia-reperfusion and Neuroprotective Drugs (review)
- VernacularTitle:脑缺血再灌注后神经细胞凋亡机制及药物保护作用的研究进展
- Author:
Ying WANG
;
Dongming XU
;
Wen WANG
;
Dongming GAO
;
Li ZHANG
;
Houxi AI
;
Lin LI
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion, apoptosis, drug, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(12):1140-1143
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion results in damage on neuron, leading to genes and proteins related to apoptosis activation. At the same time, generous cytokines released after cerebral ischemia-reperfusion can induce the apoptosis of the neuron. Many current studies have showed that the major damage mechanisms on apoptosis of the neuron are mitochondrion impairment, calcium overload, increased levels of oxygen radicals and so on. The advance research on the mechanism contributes to explore new neuroprotective drugs, and further identify the target and therapeutic effect of drug treatment.
