Expression and Significance of Plasmic Inflammatory Factor during Perioperative and Follow-up Periods after Endovascular Stents in Patients with Cerebral Arterial Stenosis
- VernacularTitle:颅内外动脉狭窄患者血管内支架成形术围术期及随访期间血浆炎性因子表达与意义
- Author:
Lianbo GAO
;
Yina LIU
- Publication Type:Journal Article
- Keywords:
cerebral arterial stenosis, endovascular stents, perioperative period/follow-up period, interleukin-6, high-sensitivity C-reactive protein
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(4):352-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe expression and significance of inflammatory factor during perioperative and follow-up periods after endovascular stents in patients with cerebral arterial stenosis.Methods 54 patients diagnosed as cerebral arterial stenosis by digital substraction angiography (DSA) were selected as the stent group and treated with endovascular stents; another 32 subjects had the same disease but not accepted stenting were considered as the control group. Interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) contents were measured at different time points during perioperative and follow-up periods in the two groups. Stage A represented as day one before angiography or catheterization; stage B as 6 hours postoperatively (stent group) or 6 hours after diagnostic angiography (control group); stages C～I as 12, 24, 48, 72 hours, 1 and 6 months after stent insertion (stent group) or the same time points after angiography (control group).Results Contents of IL-6 and hs-CRP of the stent group were similar as the control group in the stage A ( P>0.05), but significantly higher than that of the control group during stages B～I ( P<0.01～0.05). Among 54 patients of the stent group, 21 cases had restenosis 6 months postoperatively (38.89%). Contents of IL-6 and hs-CRP of the patients were similar as those without restenosis in stages A～F postoperatively ( P>0.05), but significantly higher than that of the cases without restenosis in stages G and I postoperatively ( P<0.01～0.05).Conclusion Endovascular stents can increase the contents of IL-6 and hs-CRP of patients with cerebral arterial stenosis; in addition, high expression of them is the risk factor of post-stent restenosis during follow-up period.
