Clinical Review of Subclinical Epileptiform Discharges in Children with Cerebral Palsy
- VernacularTitle:脑性瘫痪患儿伴发临床下癫痫样放电临床综述
- Author:
Jun CHEN
;
Ke WANG
;
Mei HOU
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
cerebral palsy, subclinical epileptiform discharges, clinical nature, treatment, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(4):338-340
- CountryChina
- Language:Chinese
-
Abstract:
The effects of subclinical epileptiform discharges (SEDs) on children with cerebral palsy cannot be ignored. Data from neurodevelopmental clinic studies showed that the overall incidence of SEDs in cerebral palsy was 18%～40%, with the highest in spastic hemiplegia and diplegia. The major pattern of SEDs was focal and multifocal, and was usually found in centro-temporal and parietal regions. The cortex impairment and other complications were risk factors related to SEDs in cerebral palsy. Paroxysmal or frequent long-time SEDs, with the Results of transient or chronic cognitive impairment, have been found to lead to subsequent death of cortical neurons of cerebral palsy patients thereby worsening their prognosis. Valproic acid (VPA), benzodiazepines (BZs) and lamotrigine (LTG) have a role in inhibiting SEDs, while adrenocorticotropic hormone (ACTH) and glucocorticoids have a great role in it.
