Short-course versus long-course antibiotic therapy for complicated appendicitis: A meta-analysis.
- Author:
Jayme Natasha K. Paggao
;
Omar O. Ocampo
;
Domingo S. Bongala
- Publication Type:Meta-Analysis
- Keywords:
Surgical wound infection;
anti-bacterial agents;
length of stay;
, abdominal abscess
- MeSH:
Appendectomy
- From:
Philippine Journal of Surgical Specialties
2020;75(2):141-147
- CountryPhilippines
- Language:English
-
Abstract:
OBJECTIVE:To compare the efficacy of short-course versus longcourse antibiotic therapy among patients undergoing appendectomy
for complicated appendicitis.
METHODS:The authors conducted an electronic search of PubMed,
Cochrane Library, and EBSCOHost for studies from 2000 to
January, 2000 to September, 2018 comparing short-course versus
long-course antibiotic therapy in adults undergoing appendectomy
for complicated appendicitis. The outcomes considered were the
incidence of superficial surgical site infection and intra-abdominal
abscess, and duration of hospital stay. Meta-analysis was performed
using Review Manager software.
RESULTS:A total of 360 patients in two studies were analyzed.
Superficial surgical site infection was identified in 5 out of 123 patients
in the short-course antibiotic group (4%), and 5 out of 237 patients in
the long-course antibiotic group (2.1%) (95% CI 0.38, 5.51, p=0.58).
There was a decrease in the incidence of intra-abdominal abscess in
the short-course antibiotic group (6.5%), but the difference was not
statistically significant (95% CI 0.32, 1.77, p=0.52). The duration
of hospital stay was significantly less in the short-course antibiotic
group (3.95 days) compared to the long-course antibiotic group (4.6
days) (95% CI -0.66, -0.21; p<0.001).
CONCLUSION:No difference between the <5-day and ≥5-day antibiotic
course in terms of surgical site infection and intra-abdominal abscess
was detected. However, the hospital stay of the <5-day group was
shorter.
- Full text:Short-course versus long-course antibiotic.pdf
