Reactive Oxygen Species (ROS) in Cancer and Cancer Stem Cells Spesies Oksigen Reaktif (ROS) dalam Kanser dan Kanser Stem Sel (CSC)
http://dx.doi.org/10.17576/JSKM-2021-1902
- Author:
FEBRIAL HIKMAH
1
;
NOVI SILVIA HARDIANY
2
Author Information
1. Study Program of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang, Pamulang, Tangerang Selatan, Indonesia.
2. Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Salemba Raya, Jakarta, Indonesia
- Publication Type:Journal Article
- Keywords:
ROS;
CSCs;
therapy
- From:Malaysian Journal of Health Sciences
2021;19(No.2):35-41
- CountryMalaysia
- Language:English
-
Abstract:
Reactive Oxygen Species (ROS) are aerobic metabolic byproducts, mainly produced by mitochondria. Most types of
cancer contain high amounts of ROS. An increase in endogenous ROS triggers adaptive changes, induces oxidative stress
and cytotoxic. Oxidative stress can lead to cancer. But on the other hand, the radiotherapy treatment method induces the
formation of ROS in the process of cell death. Resistance therapy in cancer cells is associated with high antioxidant
enzymes that neutralize ROS in cancer cells. In addition, therapeutic resistance and recurrence are also associated with
the presence of cancer stem cells (CSCs). Several studies have shown that ROS levels are found to be low in CSCs. Low
levels of ROS are likely to play a role in the survival of CSCs. Therefore, modulation of ROS levels in CSCs can be used
as an alternative therapy.
- Full text:14.2021my0388.pdf
