Sleep Deprivation Models in Rodents (Model Kekurangan Tidur dalam Roden)
http://dx.doi.org/10.17576/JSKM-2021-1902
- Author:
NUR SYAFIQAH MOHMED NOR
1
;
AFIFAH NAWI
1
;
WAN AMIR NIZAM WAN AHMAD
1
;
LIZA NOORDIN
1
Author Information
1. Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
- Publication Type:Journal Article
- Keywords:
Sleep deprivation;
animal models;
inverted flowerpot technique;
multiple platforms
- From:Malaysian Journal of Health Sciences
2021;19(No.2):29-38
- CountryMalaysia
- Language:English
-
Abstract:
Sleep deprivation has been identified as a risk factor for various diseases. The number of patients suffering from sleep
deprivation is increasing daily. Therefore, the risk to develop various diseases, including cardiovascular disease is
increasing. However, there is a limitation to elucidate the pathophysiological changes following sleep deprivation in
humans. Thus, the need arises for sleep deprivation models using animals, which will serve the purpose of understanding
the disease in a better way. Several techniques have been developed to model sleep deprivation in animals, including
inverted flowerpot and multiple platforms techniques. Genetic and environmental factors, costs, infrastructure and
animal life spans are some of the factors that need to be considered when selecting a particular model. Furthermore,
when studying sleep deprivation, tissue samples, such as peripheral blood, brain samples and aorta are used to elucidate
the underlying mechanisms of a particular disease. Currently, more than ninety percent of all laboratory animal
experiments are performed in rats and mice. This review article focuses on models of sleep deprivation in Rodents,
which are generally used in research laboratories. The article also tries to evaluate the advantages and disadvantages
of each technique discussed, guides the sleep deprivation model and helps researchers to decide on a specific model for
their purpose.
- Full text:14.2021my0387.pdf
