Outcomes of hepatic metastasectomy for colorectal cancer metastases in the Philippine General Hospital.
- Author:
Juan Carlos R. Abon
;
Ramon L. De Vera
;
A’Ericson B. Berberabe
;
Marc Paul J. Lopez
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
liver metastasis
- MeSH:
Metastasectomy;
Philippines
- From:
Philippine Journal of Surgical Specialties
2021;76(2):48-55
- CountryPhilippines
- Language:English
-
Abstract:
RATIONALE:The liver is the most common site of metastasis from
colorectal cancer. Curative intent liver metastasectomy has shown
improvement in overall survival. This manuscript will present
the long-term oncologic outcomes of hepatic metastasectomy for
colorectal cancer with resectable liver metastasis.
METHODS:Data of patients with resectable liver metastases from
colorectal cancer who underwent hepatic resection at the Philippine
General Hospital over a 10-year period was reviewed. The primary
outcome investigated was overall survival.
RESULTS:Thirty patients were included in the study. The median
overall survival was 20 months, with a 2-year and 5-year overall
survival rate of 40% and 6.67% respectively. Eleven (36.67%)
patients had disease recurrence, with a median disease-free survival
of 16 months. A significant difference in survival was seen between
patients with synchronous and metachronous liver metastasis (20.38
and 36.78 months respectively, p=0.0393) and in patients given
adjuvant chemotherapy at any time in relation to the occurrence of
the liver metastases versus patients who did not receive any adjuvant
treatment (34.08 and 18.59 months respectively, p=0.0349). Trends
towards improved overall survival were seen in patients 50 years
old or less (36.86 versus 21.78 months, p=0.0837) and in patients
with a clinical risk score of 2 or less (29.65 versus 19.62 months,
p=0.1823), which may show significance in a higher powered study
CONCLUSION:Improved overall survival was observed among patients
with colorectal liver metastases undergoing hepatic metastasectomy
compared to no liver resection.
- Full text:Outcomes of Hepatic Metastasectomy.pdf
