Effect of Pulsed Magnetic Field Therapy on Expression of Platelet-Derived Growth Factor-A after Carotid Endarterectomy
- VernacularTitle:脉冲磁场对颈动脉内膜切除术后血管内膜血小板衍生生长因子表达的影响
- Author:
Yanmei GUO
;
Wei SUO
;
Yueming GAO
;
Caixing ZHU
- Publication Type:Journal Article
- Keywords:
carotid endarterectomy (CEA), restenosis, atherosclerosis, pulsed magnetic field, platelet-derived growth factor (PDGF)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(3):223-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different dosage of pulsed magnetic field on expression of platelet-derived growth factor-A (PDGF-A) in rabbits with carotid atherosclerosis after carotid endarterectomy (CEA). Methods Carotid atherosclerosis were modeled in 50 New Zealand rabbits with air-drying lesion combined with high fat feed. All animals were treated with double side carotid endarterectomy after 2 months, and were randomly divided 3 groups: 0.6 T group, 1.0 T group and the blank control. The expression of platelet-derived growth factor-A were detected with immunohistochemistry 1 month, 2 months and 3 months after CEA. Results The expression of PDGF-A in treated groups were lower significantly than that in controls (P<0.05) 2 month after CEA, and it was the lowest in 1.0 T group, lower in 0.6 T group 3 month after CEA. Conclusion The pulsed magnetic field therapy can decrease the expression of PDGF-A, which might be helpful to prevent the carotid from restenosis.
