Smoking Associated with Aspirin and Clopidogrel Resistance in Patients with Stable Angina after Percutaneous Coronary Intervention
- VernacularTitle:吸烟对冠心病心绞痛型患者经皮冠状动脉介入治疗术后二联抗血小板疗效的影响
- Author:
Ming YE
;
Yan QIAO
;
Chang LIU
;
Yan YAN
;
Nan LI
- Publication Type:Journal Article
- Keywords:
smoking, aspirin resistance, aspirin semiresponder, Clopidogrel resistance, angina, percutaneous coronary intervention
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(11):1057-1059
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the association of smoking to the Aspirin and Clopidogrel antiplatelet in patients with stable angina after percutaneous coronary intervention (PCI). Methods241 smoking patients and 252 non-smoking patients underwent PCI for stable coronary artery disease, all patients had taken aspirin 100 mg/d for 7 d or more. The arachidonic acid (AA)- and adenosine diphosphate (ADP)-induced platelet aggregation were tested as they got in hospital. Then, they accepted Clopidogrel 300 mg as loading dose, continued with 75 mg/d for 3 d. The ADP-induced platelet aggregation were re-tested. ResultsThe incidence of aspirin resistance (AR) and aspirin semiresponder (ASR) was 19.1% in all the cases, and was 25.5% in smoking group, 14.3% in non-smoking group (P=0.027). Age (OR=3.79，95%CI: 1.77～8.12) and smoking (OR=1.98，95%CI: 1.18～4.43) were the independent risk factors of AR and ASR. The incidence of Clopidogrel resistance was 19.5% in all the cases, and was 13.2% in smoking group, 24.3% in non-smoking group (P=0.03). Smoking (OR=0.22，95%CI: 0.09～0.54) may reduce the risk of Clopidogrel resistance. ConclusionSmoking increased the risk of AR and ASR, but reduced the risk of Clopidogrel resistance.
