Applications and constructions of benzazepine scaffolds in drug molecular design
10.16438/j.0513-4870.2022-0876
- VernacularTitle:苯并氮杂䓬在药物分子设计中的应用及构建
- Author:
Bo HAN
;
Xin-yan PENG
;
Jian-qi LI
;
Qing-wei ZHANG
- Publication Type:Research Article
- Keywords:
benzazepine;
structure optimization;
rug molecule;
privileged scaffold;
ruggability
- From:
Acta Pharmaceutica Sinica
2022;57(12):3564-3575
- CountryChina
- Language:Chinese
-
Abstract:
Benzazepine is a kind of fused ring structure, which is composed of nitrogen-containing seven-membered ring and benzene ring. The introduction of benzazepine scaffolds into compounds can not only adjust the physicochemical properties, maintain or enhance the biological activities of the compounds, but also improve the pharmacokinetic properties, increase the brain permeability, and reduce the toxicity of hERG of the compounds, which is one of the privileged scaffolds for rational design and structural optimization of drug molecules. Benzazepine scaffolds can be constructed by different synthetic methods such as Dickmann condensation reaction, Mitsunobu reaction, Pictet-Spengler reaction, CMD reaction, multicomponent reactions (MCRs), metal catalysis reactions and asymmetric catalysis etc., which play an important role in enriching the structure diversity of drug molecules.
