Progress on the neuroprotective effects of ginsenoside Rg1

Jun-peng Long; Yang Sun; Sha-sha Liu; Jiao Yao; Song-wei Yang; Yan-tao Yang; Gang Pei; Lei Meng; Qi-di AI; Nai-hong Chen

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Progress on the neuroprotective effects of ginsenoside Rg1

VernacularTitle:人参皂苷Rg1的神经保护作用研究进展
Author: Jun-peng LONG ^{1
,

2} ; Yang SUN ^{1
,

2} ; Sha-sha LIU ³ ; Jiao YAO ^{1
,

2} ; Song-wei YANG ^{1
,

2} ; Yan-tao YANG ^{1
,

2} ; Gang PEI ^{1
,

2} ; Lei MENG ^{1
,

2} ; Qi-di AI ^{1
,

2} ; Nai-hong CHEN ^{1
,

2
,

4}
Author Information

1. College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
2. Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208, China
3. Xiangtan Central Hospital, Xiangtan 411199, China
4. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Publication Type:Research Article
Keywords: ginsenoside Rg1; neuroprotection; neurodegenerative disease; Alzheimer's disease; stroke
From: Acta Pharmaceutica Sinica 2023;58(1):21-26
CountryChina
Language:Chinese
Abstract: Ginsenoside Rg1 is one of the most important saponins in ginseng. It has a wide range of pharmacological activities. It is considered to be a powerful neuroprotective agent. It has neuroprotective effects such as anti-neuroinflammation, anti-oxidative stress, anti-neuronal apoptosis, and enhancing memory. Rg1 shows a good application prospect in the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, stroke, and mental diseases such as depression. This paper reviews the research on the neuroprotective mechanism of Rg1 at home and abroad in recent years, in order to provide new research ideas for the clinical treatment of nervous system diseases.