Application and mechanism of nanomedicine and nanomaterials in antibacterial infection therapy
10.16438/j.0513-4870.2022-0615
- VernacularTitle:纳米材料和纳米药物递释系统在抗细菌感染中的应用及机制
- Author:
Ying-ying HE
;
Wen-bo ZHOU
;
Qi-wei TAI
;
Rong-jie LI
;
Yuan YU
- Publication Type:Research Article
- Keywords:
bacterial infection;
antibacterial agent;
antibiotic resistance;
inorganic nanomaterial;
nano-drug delivery system
- From:
Acta Pharmaceutica Sinica
2023;58(1):106-117
- CountryChina
- Language:Chinese
-
Abstract:
Antibacterial therapy is a global health issue. The antibiotic resistance is becoming an increasingly serious threat, which caused by misuse and overuse of antibacterial agents combined with the emergence of new resistance mechanism. The resulting infection treatment risk and incidence of the spread of disease, severe cases and deaths are increased in different degrees. With the extensive application of biomaterials and nanotechnology to biomedicine, extensive research has been conducted on antibacterial infection. With the specific physicochemical properties like optical, electric and magnetic and high penetration, inorganic nanomaterials can produce natural antibacterial effect. Nanomedicine can be designed to allow controlled drug release and targeting effect, thus demonstrated better antibacterial efficiency. In this review, the mechanism of antibacterial resistance is described, and the antibacterial infection research on inorganic nanomaterials, as well as nano-drug delivery system including liposomes, nanoparticles, dendrimers and biomimetic nanocarriers are summarized. Nanomaterials and nanotechnology offer promising strategies for the development of new agents that can improve efficacy on antibacterial infections and overcome antibiotic resistance potentially.
