Advance of hair follicle targeted drug delivery systems in the treatment of acne and hair loss

VernacularTitle:毛囊靶向递药系统及其在痤疮和脱发治疗中的研究进展
Author: Sha XIONG ; Zi-yi LIU ; Ting XIAO ; Yue-hong XU
Publication Type:Research Article
Keywords: hair follicle targeted; acne; hair loss; nano-based drug delivery system; percutaneous permeation
From: Acta Pharmaceutica Sinica 2023;57(1):95-105
CountryChina
Language:Chinese
Abstract: Hair follicle (HF), one of the skin appendages, has received a lot of attention to be a new target and pathway for drug delivery. The development of hair follicle targeted drug delivery system (HFTDDS) through percutaneous permeation is particularly important for skin diseases derived from HF such as acne, hair loss, and folliculitis for their on-site action. This review describes the structure and physiological function of HF, the microenvironment of HF, and factors affecting HF permeation. Multiple nanoformulations used to improve the HF permeation and technologies to characterize the HF permeation were introduced. The latest advance of HFTDDS based on nanoformulations were systematically summarized and analyzed in the treatment of acne and hair loss. Finally, the challenges of formulating HFTDDS were discussed. The review is expected to provide some ideas and references for developing delivery systems for treating skin diseases derived from HF.