Research progress of polymer self-healing mechanism and its application in biomedicine
10.16438/j.0513-4870.2022-0564
- VernacularTitle:聚合物自愈合机制及在生物医药领域的应用研究进展
- Author:
Jin-yue WANG
1
,
2
;
Jin-wei DI
3
;
Li-xun LÜ
1
;
Ai-ping ZHENG
3
;
Lin-lin ZHAO
1
;
Jing GAO
3
Author Information
1. North China University of Science and Technology, Tangshan 063210, China
2. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Academy of Military Sciences, Beijing 100850, China
3. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Academy of Military Sciences, Beijing 100850, China
- Publication Type:Research Article
- Keywords:
self-healing;
covalent bond;
non-covalent bond;
rug-delivery;
tissue-engineering
- From:
Acta Pharmaceutica Sinica
2023;58(1):86-94
- CountryChina
- Language:Chinese
-
Abstract:
Polymer self-healing is mainly based on the molecular structure and interaction of polymers, and some need external stimulation, such as light, heat, pH, etc. In recent years, many studies have found that the self-healing properties of polymers can prolong the life of materials, while maintaining the mechanical properties of polymers after healing. According to the different action modes of polymer materials, it can be divided into autonomous self-healing and non-autonomous self-healing. Among them, autonomous self-healing mainly works through reversible covalent bonds (Schiff base bond, Diels-Alder reaction, hydrazide bond), reversible non-covalent bonds (hydrogen bond, metal-ligand coordination bond, electrostatic interaction, π-π stacking interaction, hydrophobic interaction) and a combination of the two interactions. Drug carriers with unique self-healing properties play an important role in the encapsulation and stable release of biomacromolecules. In this review, the self-healing mechanism of polymers and their applications in the field of biomedicine were briefly summarized and discussed.
