Chemical Constituents and Biological Activities of Mitrella Kentii (Blume) Miq. Leaf Oil (Komponen Kimia dan Aktiviti Biologi Minyak Daun Mitrella Kentii (Blume) Miq.)
http://dx.doi.org/10.17576/JSKM-2021-1901-17
- Author:
JURIYATI JALIL
1
;
SAKINA SAADAWI
1
;
IBRAHIM JANTAN
1
,
2
;
MALINA JASAMAI
1
Author Information
1. Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia&
2. School of Pharmacy, Taylors University, Lakeside campus, Subang Jaya, Selangor 47500, Malaysia
- Publication Type:Journal Article
- Keywords:
Mitrella kentii;
platelet-activating factor (PAF);
prostaglandin E2 (PGE2 );
thromboxane B2 (TXB2 );
DPPH assay
- From:Malaysian Journal of Health Sciences
2021;19(No.1):151-159
- CountryMalaysia
- Language:English
-
Abstract:
Chemical constituents and biological activities of the Mitrella kentii leaf oil were investigated in this study. Gas
chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were used to determine the chemical
constituents of the oil. The oil was evaluated for its ability to inhibit prostaglandin E2
(PGE2
) and thromboxane B2
(TXB2
) productions in human whole blood using a radioimmunoassay technique. Its inhibitory effect on plateletactivating factor (PAF) receptor binding with rabbit platelets using 3
H-PAF as a ligand and its free radical scavenging
effect on DPPH were also investigated. Caryophyllene oxide (33.8%w/w), E,Z-farnesol (6.9%), benzyl benzoate
(6.5%w/w) and viridiflorol (6.5%w/w) were among the major components of the oil. Even though weak inhibitory
activities were observed in both PGE2
and TXB2
assays, significant results were obtained in both PAF receptor binding
inhibition and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging effect with IC50 value of 6.6 µg/mL and 155.6 µg/mL
respectively. These promising activities warrant the development of the oil as an anti-inflammatory agent.
- Full text:14.2021my0381.pdf
