A Case of Wolfram Like Disorder with Type 2 Diabetes Mellitus in an Adult.
10.3803/EnM.2010.25.2.131
- Author:
Sung Uk CHOI
1
;
Soo Kyung BAE
;
Hyun Soo KIM
;
Kyung Rok KIM
;
Ki Hwan HUR
;
Sung Hyup LIM
;
Young Ae HONG
;
Sung Chang CHUNG
Author Information
1. Department of Internal Medicine, Dongkang Medical Center, Ulsan, Korea. jusi430@hanmail.net
- Publication Type:Case Report
- Keywords:
Wolfram like disorder;
WFS1-related disorder;
Wolfram syndrome
- MeSH:
Adult;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Female;
Hearing Loss;
Hearing Loss, Sensorineural;
Humans;
Molecular Biology;
Mutation, Missense;
Optic Atrophy;
Phenotype;
Tungsten;
Wolfram Syndrome
- From:Endocrinology and Metabolism
2010;25(2):131-134
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wolfram-like disorder is one of the WFS1-related disorders that are caused by mutation of the WFS1 genes. WFS1-related disorders are classified as Wolfram syndrome, Wolfram like disorder and nonsyndromic low-frequency sensorineural hearing loss (DFNA6/14/38). Wolfram syndrome is known to DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness), and it is an autosomal-recessive disorder that predisposes a patient to developing type 1 diabetes in association with progressive optic atrophy, and the disease shows various phenotypes. Wolfram like disorder is an autosomal-dominant disorder that predisposes a patient to develop type 2 diabetes in association with optic atrophy and hearing impairment. We experienced a case of Wolfram like disorder with diabetes, optic atrophy and sensorineural hearing loss in a 28-year-old woman who was admitted to our hospital. Our case demonstrated the E737K missense mutation on the WFS1 gene, which has been previously reported in the medical literature. The diagnosis of WFS1-related disorder was confirmed by the clinical features and molecular genetic testing of the WFS1 gene.
