Effects of Morroniside on IL-1β in Rat Cortex with Focal Cerebral Ischemia/Reperfusion
- VernacularTitle:莫诺苷对局灶性脑缺血再灌注大鼠皮层IL-1β的影响
- Author:
Houxi AI
;
Ying WANG
;
Dongming XU
;
Wen WANG
;
Dongming GAO
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
morroniside, cerebral ischemia/reperfusion, IL-1β, antiinflammatory, neuroprotective
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(10):928-930
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of morroniside on IL-1β in rat cortex with focal cerebral ischemia/reperfusion.MethodsThe animal model was induced by occlusion of middle cerebral artery with suture embolus, ischemia for 30 min, and reperfusion for 72 h in rats. The content of IL-1β was detected with enzyme linked immunosorbent assay(ELISA).ResultsCompared with sham group, the content of IL-1β increased obviously in model rat. Compared with model group, morroniside(30 mg/kg, 90 mg/kg, 270 mg/kg) and colchicine (0.06 mg/kg) decreased the content of IL-1β significantly (P<0.001).ConclusionMorroniside may protect the cortex from inflammatory factor IL-1β.
