Pharmacological Mechanism of Jintong Capsule on Tourette Syndrome Rat Model Induced by Iminodipropionitrile
- VernacularTitle:金童颗粒治疗拟抽动秽语综合征模型大鼠的药理机制研究
- Author:
Ruyi ZHANG
;
Li ZHANG
;
Houxi AI
;
Cuifei YE
;
Xuejing SUN
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Tourette syndrome, stereotyped behaviors, dopamine, animal model, Jintong capsule
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(10):910-912
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of Jintong capsule on model rats of Tourette syndrome (TS) and explore its probable pharmacological mechanisms.MethodsSD rats were randomly divided into six groups: blank control, TS model, haloperidol and three Jintong capsule treated groups. Model rats were copied by intraperitoneal injection of iminodipropionitrile (IDPN). The stereotyped behaviors of model rats were recorded. Open field test was used to detect ability of space recognition of rats, high performance liquid chromatography was used to detect content of monoamines, and flow cytometry was used to detect the ratio of T lymphocyte.ResultsJintong capsule can ameliorate the stereotyped behaviors of model rats, decrease content of dopamine in striatum and increase the ratio of CD4/CD8.ConclusionJintong capsule can improve behaviors of model rats. The potential mechanism of Jintong capsule maybe: it can affect the dopaminergic system of model rats, and Jintong can enhance the immune system of model rats.
