Therapeutical Effects of Rehmannia and Storesin on Minimal Hepatic Encephalopathy in Rat Mode
- VernacularTitle:地黄苏合香合剂对轻微肝性脑病模型大鼠治疗的实验研究
- Author:
He LIU
;
Yan LIANG
;
Yanyong LIU
;
Nan YANG
;
Chao JI
;
Pingping ZUO
;
Tao GONG
;
Lei LIAO
;
Xiaoming HOU
;
Zhe CAI
- Publication Type:Journal Article
- Keywords:
rehmannia, storesin, minimal hepatic encephalopathy, behavior, alanine transarninase, ammonia
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(10):904-906
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the effects of rehmannia and storesin on minimal hepatic encephalopathy(MHE) in rat model.MethodsMHE rat model was induced by carbon tetrachloride (CCl4) intragastric administration. The effects of rehmannia and storesin on spontaneous movement and learning and memory function of model animals were evaluated with open field test and Morris water maze in 3 dose groups. Lactulose was used in the positive group.ResultsThe spontaneous movement and the spatial learning and memory ability of the model rats both improved significantly in the high dose group. Meanwhile, the serum level of alanine transarninase(ALT) and ammonia(Amm) also decreased in the high dose group.ConclusionRehmannia and storesin has therapeutical effect on MHE rat model.
