A Locally Advanced Breast Cancer with Difficult Differential Diagnosis of Carcinosarcoma and Atypical Medullary Carcinoma, which had Poor Response to Adriamycin- and Taxane-based Neoadjuvant Chemotherapy: A Case Report.
- Author:
Se Hyun KIM
1
;
Hyun Cheol CHUNG
;
Jaeheon JEONG
;
Ji Hoon KIM
;
Sun Young RHA
;
Joong Bae AHN
;
Nam Hoon CHO
;
Hei Cheul JEUNG
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. Jeunghc1123@yuhs.ac
- Publication Type:Case Report
- Keywords:
Atypical medullary carcinoma;
Carcinosarcoma;
Metaplastic breast cancer;
Neoadjuvant chemotherapy
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinoma, Medullary*;
Carcinosarcoma*;
Diagnosis;
Diagnosis, Differential*;
Drug Therapy*;
Humans;
Mastectomy, Modified Radical;
Middle Aged;
Paclitaxel;
Prognosis
- From:Cancer Research and Treatment
2007;39(3):134-137
- CountryRepublic of Korea
- Language:English
-
Abstract:
Atypical medullary carcinomas and carcinosarcoma have unique histopathological features. Here we present a case with a breast malignancy that had pathological characteristics of both. A 54-year old patient with a malignant breast mass received 6 cycles of adriamycin-based chemotherapy, followed by 3 cycles of paclitaxel monotherapy, and had a poor clinical response to treatment. A modified radical mastectomy was performed. The pathological diagnosis was complicated by an inability to distinguish between atypical medullary carcinoma and carcinosarcoma. The findings included a tumor that was well-circumscribed, high grade and a syncytial growth pattern as well as biphasic sarcomatous and carcinomatous characteristics. In conclusion, atypical medullary carcinoma and carcinosarcoma of the breast have entirely different prognoses and should be managed differently. Both should be treated by surgical resection, and additional therapy should be considered based on the cancer with the poorer prognosis.
