Genetic susceptibility factors of rheumatoid arthritis.
- Author:
Hye Soon LEE
1
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Hanyang University College of Medicine, Guri, Korea.
- Publication Type:Review
- Keywords:
Rheumatoid arthritis;
Gene, Genome-wide association study
- MeSH:
Arthritis;
Arthritis, Rheumatoid;
Autoimmune Diseases;
Case-Control Studies;
Genetic Association Studies;
Genetic Predisposition to Disease;
Genome-Wide Association Study;
HLA-DRB1 Chains;
Joints
- From:Korean Journal of Medicine
2008;75(5):515-524
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly involves the joints. Although the full etiology remains unclear, both genetic and environmental factors contribute to disease. Recently, genetic studies of RA, which include whole-genome linkage study, candidate gene association study, and especially genome-wide association study, made much progress through the advances in technology and large collection of case-controls. These various approaches provided new susceptible genes such as PTPN22, PADI4, STAT4, TNFAIP3, TRAF1-C5, CD40 gene in addition to HLA-DRB1. This review will cover an update in recent progress in RA genetics, focusing mainly on the several novel loci.
