Clinical Relevance of Urokinase-type Plasminogen Activator ( uPA ) , uPA Receptor , Plasminogen Activator Inhibitor-1 Co-expression from Tissue and Serum of Breast Cancer as Targets of Biotherapy.
- Author:
Sun Young RHA
1
;
Joon Oh PARK
;
Soo Jung GONG
;
Se Ho PARK
;
Nae Choon YOO
;
Woo Ick YANG
;
Jae Kyung ROH
;
Jin Sik MIN
;
Kyong Sik LEE
;
Byung Soo KIM
;
Hyun Cheol CHUNG
Author Information
1. Yonsei Cancer Center
- Publication Type:Original Article
- Keywords:
uPA;
uPAR;
PAI-1;
Breast cancer;
Tissue;
Blood
- MeSH:
Biological Therapy*;
Breast Neoplasms*;
Breast*;
Carcinoma, Intraductal, Noninfiltrating;
Enzyme-Linked Immunosorbent Assay;
Humans;
Plasminogen Activator Inhibitor 1;
Plasminogen Activators*;
Plasminogen*;
Urokinase-Type Plasminogen Activator*
- From:Journal of the Korean Cancer Association
1999;31(2):256-266
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We measured and compared the uPA, plasminogen activator inhibitor-1 (PAI-1) and uPA receptor (uPAR) levels in breast cancer tissues and blood of the patients to evaluate their clinical relevance for biotherapy. MATERIALS AND METHODS: uPA, PAI-1 (Monozyme, Netherland), uPAR (American Diagnostics, USA) levels were measured by ELISA assay in 192 breast cancer tissues, in 18 normal breast tissues and in 163 blood from breast cancer patients. RESULTS: There was a tendency of uPA increment from ductal carcinoma in situ while increment of PAI-1 and uPAR occurred from Ti. With the progression of cancer, uPA, PAI-1, uPAR tended to decrease; however, the uPA/uPAR, uPA/PAI-1 ratios remained unchanged. There was a correlation of uPA expression between normal and cancer tissues ( r(2)= 0.49). Correlation of uPA and PAI-1 was found in normal tissue and stage I cancer tissue while correlation of uPAR and PAI-1 was found with cancer progression. Between cancer tissue and blood significant correlations were found in uPA, PAI-1, uPAR levels. CONCLUSION: uPA, PAI-1, uPAR levels in cancer tissue elevated from the early stage maintaining correlative expressions with cancer progression. A positive correlation between cancer tissue and blood level suggested the applicability of the levels of uPA, PAI-1 or uPAR for detecting patients for biotherapy.
