Cause Analysis and Solution Strategy of Poor Solubility of Dioscoreae Rhizoma Formula Granules
10.13422/j.cnki.syfjx.20220750
- VernacularTitle:山药配方颗粒溶化性差的原因分析与解决策略
- Author:
Wei LIAO
1
;
Dingkun ZHANG
1
;
Zhiping GUO
2
;
Shifa RUAN
3
;
Chunli GE
1
;
Jiabao LIAO
3
;
Li HAN
1
Author Information
1. School of Pharmacy，State Key Laboratory of Southwestern Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
2. Sichuan Houde Pharmaceutical Technology Co. Ltd.，Chengdu 610041，China
3. China Resources Sanjiu Modern Chinese Medicine Pharmaceutical Co. Ltd.，Shenzhen 518110，China
- Publication Type:Journal Article
- Keywords:
Dioscoreae Rhizoma;
traditional Chinese medicine formula granules;
solubility;
microstructure;
spray drying;
powder modification technology;
starch
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(7):193-198
- CountryChina
- Language:Chinese
-
Abstract:
Dioscoreae Rhizoma formula granules are made from decoction pieces by decocting， extracting， separating， concentrating， drying and granulating， which have the advantages of simple dispensing， convenient use and easy to take without decoction. However， because Dioscoreae Rhizoma is rich in starch and mucus components， its extract powder and formula granules are poorly soluble and difficult to dissolve or disperse completely within 5 min， and the insoluble material is difficult to dissolve completely even after 24 h in water， which affects the quality evaluation of the formula granules and medication psychology of patients. Therefore， by studying the dissolution process and mechanism of Dioscoreae Rhizoma extract and its formula granules， it was found that the special chemical composition of Dioscoreae Rhizoma， the denaturation of starch and its compounding with protein and other substances during the high temperature extraction process， and the contraction of coating membrane during the spray drying process were combined to form the special microstructure of coating membrane covering starch granules， and it is the root cause of poor solubility of Dioscoreae Rhizoma formula granules. Based on the research on the structure， property and function of the powder， this paper proposed a technical strategy to improve the solubility of Dioscoreae Rhizoma formula granules by powder modification process， and experimentally demonstrated that the modified Dioscoreae Rhizoma formula granules could completely dissolve within 2 min， which solved the technical problem and could provide reference for the improvement of solubility of other similar varieties， and promote the high-quality development of traditional Chinese medicine formula granule industry.
