Qiju Dihuangtang Combined with Chinese Medicine Fumigation in Treatment of Dry Eye and Its Effect on Levels of Tear IL-6 and MMP-9
10.13422/j.cnki.syfjx.202201822
- VernacularTitle:杞菊地黄汤加减联合中药熏蒸治疗干眼症及对泪液IL-6、MMP-9水平的影响
- Author:
Zhongsi LIN
1
;
Xiaobin YU
1
;
Zheng ZHANG
1
;
Huiyang SHI
2
;
Tao ZUO
2
;
Lei ZHAO
2
Author Information
1. Shandong College of Traditional Chinese Medicine（TCM）， Yantai 264199， China
2. The Second Affiliated Hospital of Liaoning University of TCM， Shenyang 110034， China
- Publication Type:Journal Article
- Keywords:
dry eye;
Qiju Dihuangtang;
fumigation with Chinese medicine;
clinical efficacy;
inflammatory factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(7):133-138
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of Qiju Dihuangtang combined with Chinese medicine fumigation in the treatment of dry eye and its effect on the levels of interleukin-6 （IL-6） and matrix metalloproteinase-9 （MMP-9） in tears. MethodA total of 120 patients with dry eye of liver-kidney Yin deficiency syndrome who were treated in the Department of Ophthalmology， The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine（TCM） from october 2019 to october 2021 were randomized into the observation group and control group. The control group was given sodium hyaluronate eye drops， and the observation group was treated with sodium hyaluronate eye drops， Qiju Dihuangtang， and Chinese medicine fumigation. The treatment lasted 30 days for both groups. The changes of ocular surface disease index （OSDI）， TCM syndrome score， tear secretion （SIT）， tear film breaking up time （BUT）， corneal fluorescein staining （FL）， and tear interleukin-6 （IL-6） and matrix metalloproteinase-9 （MMP-9） were observed. ResultAfter the treatment， the total effective rate was 90.0% （54/60） in the observation group and 75.0% （45/60） in the control group （χ2=4.675， P<0.05）. After treatment， the OSDI score and TCM syndrome score were lower than those before treatment in both groups （P<0.05）， and lower in the observation group than in the control group （P<0.05）. After treatment， the SIT and BUT were higher （P<0.05） and FL score was lower （P<0.05） than those before treatment in both groups. After treatment， the improvement of the above indicators in the observation group was better than that in the control group （P<0.05）. After treatment， the levels of IL-6 and MMP-9 were lower than those before treatment in both groups （P<0.05）， and lower in the observation group than in the control group （P<0.05）. ConclusionQiju Dihuangtang combined with Chinese medicine fumigation can effectively improve subjective symptoms， promote tear secretion， prolong BUT， enhance corneal epithelial repair， and reduce the levels of tear IL-6 and MMP-9 in the treatment of dry eye.
