Effect of YQHXFF on Expression of Matrix Metalloproteinase-2 after Percutaneous Transluminal Coronary Angioplasty in Rabbits with Hyperlipidemia

VernacularTitle:益气活血复方对兔颈总动脉球囊损伤后基质金属蛋白酶-2 mRNA表达的影响
Author: Huiwu LIU ; Yan ZHANG ; Hongbo SUN
Publication Type:Journal Article
Keywords: YQHXFF, percutaneous transluminal coronary angioplasty (PTCA), matrix metalloproteinase-2 （MMP-2）
From: Chinese Journal of Rehabilitation Theory and Practice 2009;15(1):41-43
CountryChina
Language:Chinese
Abstract: : Objective To observe the effects of YQHXFF on the expression of matrix metalloproteinase-2 （MMP-2） in the rabbits with hyperlipidemia after percutaneous transluminal coronary angioplasty (PTCA). Methods 28 male New Zealand white rabbits were randomly divided into the control group, the model group and the YQHXFF intervention group. The models of restenosis were established with injuring carotid arteries in cholesterolfied rabbits. After 8 weeks, MMP-2 were measured with reverse transcription polymerize chain reaction (RT-PCR) and pathologic alter were observed with HE staining. Results The expression of MMP-2 mRNA in injured artery were much higher in the model group. Compared with those in the model group, the expression of MMP-2 in the YQHXFF intervention group markedly decreased and intimal hyperplasia markedly lighten. Conclusion YQHXFF can inhibit the expression of MMP-2 and lighten the intimal hyperplasia after PTCA.