Cardiac Remodeling in Apolipoprotein E-deficient Mice with Cholesterol-fed
- VernacularTitle:高胆固醇喂养ApoE基因缺陷小鼠的心脏改变
- Author:
Yan QIN
;
Ping YE
;
Lvya WANG
;
Ya YANG
- Publication Type:Journal Article
- Keywords:
apolipoprotein E gene deficient mice, myocardium, collagen, cholesterol
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the dynamic changes in cardiac morphology and myocardial collagen in apolipoprotein E-deficient (apoE-/-) mice of different age with cholesterol-fed. Methods 18 male apoE-/- mice were randomized into 3 groups: 24 weeks group （n=6）, 32 weeks group （n=6）, 40 weeks group （n=6）. 8 C57BL/6J mice were set as the control. Serum cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride, high-density lipoprotein cholesterol (HDL-C) were determined. The cardiac morphological changes and the myocardial collagen were observed. Results Compared with the 24 weeks group, the content of myocardial collagen of 32 and 40 weeks group significantly increased (P<0.05). Conclusion With the increasing of age, TC significantly increased, myocardial collagen content tended to go up.
