Electrophysiology and Magnetic Resonance Imaging of Hereditary Spastic Paraplegia with Thin Corpus Callosum: 3 Cases Report
- VernacularTitle:遗传性痉挛性截瘫伴薄型胼胝体的电生理和磁共振成像
- Author:
Fang CUI
;
Xusheng HUANG
- Publication Type:Journal Article
- Keywords:
hereditary spastic paraplegia, thin corpus callosum, clinic, electrophysiology, magnetic resonance imaging (MRI), genetics
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(1):30-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). Methods Clinical, electrophysiological, MRI features of 3 patients with HSP-TCC were reported. The genetic characteristics were reviewed. Results 3 patients revealed difficulty in walking, slowly progressive weakness, spasticity of the lower limbs and mental impairment. The electromyogram in 2 cases showed neurogenic damage in lower limbs muscle, and 1 case showed peripheral nerve damage. Cerebral MRI showed an extremely thin corpus callosum on sagittal image. The locus of 15q13-15 has been identified for HSP-TCC, but some HSP-TCC families have not been linked to this locus.Conclusion HSP-TCC is a common subtype of complicated HSP inherited by autosomal recessive mode. Brain MRI showed extremely thin corpus callosum. Electromyogram many reveal neurogenic damage.
