Expression of N-cadherin and β-catenin mRNA in Human Brainstem or Supratentorial Gliomas
- VernacularTitle:人脑干和幕上胶质瘤N-cadherin和β-catenin mRNA的表达
- Author:
Junyan MA
;
Wenhao WU
;
Yongji TIAN
;
Junhua LI
;
Liwei ZHANG
;
Hong WAN
;
Shuyu HAO
;
Dezhi LI
;
Luxin YIN
- Publication Type:Journal Article
- Keywords:
glioma, N-cadherin, β-catenin, brainstem, supratentorial
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(9):856-858
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the expression of N-cadherin and β-catenin mRNA in human brainstem and supratentorial gliomas. MethodsN-cadherin and β-catenin mRNA expression in 18 cases of brainstem gliomas and 18 cases of supratentorial gliomas tissues were detected with PT-PCR. Resultsβ-catenin mRNA expression was more in human brainstem gliomas than in supratentorial gliomas （t=2.255,P<0.05）, but was not significantly different of N-cadherin mRNA (P＞0.05). The expression of N-cadherin mRNA in human brainstem gliomas of grades Ⅰ～Ⅱ were less than those in human gliomas of grades Ⅲ～Ⅳ (t=2.711，P<0.05), but was not of β-catenin mRNA (P＞0.05). N-cadherin mRNA expression was positively correlated with the β-catenin mRNA expression in either brainstem gliomas or supratentorial gliomas （r=0.480，r=0.809 respectively, P<0.05）. ConclusionThe over expressions of N-cadherin and β-catenin may play an important role in the invasion and malignant progress of human brainstem gliomas.
