A Systematic Review of the Role of Mitochondria in Cleft Pathology: A Forgotten General?
10.21315/aos2022.1701.RV03
- Author:
Rabiatul Adawiyah Mohamad Noor
1
;
Wan Azman Wan Sulaiman
1
;
Anani Aila Mat Zin
2
;
Nurul Syazana Mohamad Shah
1
Author Information
1. Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2. Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
- Publication Type:Review
- Keywords:
Cleft;
Non-syndromic;
Mitochondrial DNA;
Mitochondrial myopathy;
Orbicularis oris muscle
- MeSH:
Mitochondria--pathology;
DNA, Mitochondrial;
Cleft Lip;
Cleft Palate
- From:Archives of Orofacial Sciences
2022;17(1):21-30
- CountryMalaysia
- Language:English
-
Abstract:
ABSTRACT:Orofacial clefts (OFC) are one of the most common birth defects that affects the lip, palate, or lip
and palate of an infant. The deterioration of clefts is multifactorial involving multiple genes, various
interactions from environmental factor and most forgotten, mitochondrial abnormality. The aim of this
review is to highlight the importance of mitochondrial activity related to non-syndromic OFC deformity.
Despite its important role in cells, the study on mitochondrial activity in cleft pathology was scarce and
almost forgotten compared to other genetic investigations. This systematic review was completed based
on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The
literature search was done via the following databases: Google Scholar, Pubmed and Scopus with a total
of nine studies of mitochondrial abnormalities were included. We hypothesise that mitochondria play an
important role in early craniofacial development. A decreased in its function or activity may result in cleft
lip formation. Hence, we would like to shed light on the remarkable role of mitochondria activity in the
pathogenesis of non-syndromic OFC.
- Full text:2.2022my0003.pdf
