Application progress of parallel artificial membrane permeation assay model in drug permeability screening of transdermal drug delivery system
- VernacularTitle:平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展
- Author:
Sankong SONG
1
;
Yinliang BAI
1
;
Jiandi LIANG
1
Author Information
1. Dept. of Pharmacy，the Second Hospital of Lanzhou University，Lanzhou 730030，China
- Publication Type:Journal Article
- Keywords:
transdermal drug delivery system;
parallel artificial membrane permeation assay;
drug penetration screening
- From:
China Pharmacy
2023;34(4):502-507
- CountryChina
- Language:Chinese
-
Abstract:
The traditional model Franz diffusion cell method has always been the “gold standard” for evaluating the permeability of transdermal drug delivery system （TDDS） drug. However， in the high throughput screening of a large number of drug molecules， it has the disadvantages of low efficiency， high cost， difficulty to obtain isolated skin，poor reliability and large workload. The emergence of parallel artificial membrane permeation assay （PAMPA） model provides reliable pre-prediction data for the evaluation of permeability of TDDS drug. PAMPA model has been widely used in the permeability screening research of TDDS drugs and their preparations such as analgesics， local anesthetics， antioxidants， antipyretics， analgesics and anti-inflammatory drugs， vitamins， cholinesterase inhibitors， active ingredients of natural products， and has the characteristics of high reliability， good selectivity， high efficiency， low cost and data stability. PAMPA model has greatly improved the high throughput screening efficiency of TDDS drug permeability. With the extensive application and gradual maturity of this model， it will become a new and effective evaluation method in addition to the traditional evaluation model.
