Comparison of anti-ischemic stroke effect of different extraction parts from Gastrodia elata
- VernacularTitle:天麻不同提取部位抗缺血性脑卒中作用比较
- Author:
Chunping XU
1
;
Qian YANG
1
;
Qingting MENG
1
;
Mingli YAN
1
;
Long NING
1
;
Hang SUN
1
;
Fangyan HE
1
Author Information
1. College of Traditional Chinese Medicine，Yunnan University of Traditional Chinese Medicine，Kunming 650500，China
- Publication Type:Journal Article
- Keywords:
Gastrodia elata;
ischemic stroke;
extraction part;
pharmacodynamics;
effective part
- From:
China Pharmacy
2023;34(4):429-432
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To compare anti-ischemic stroke （IS） effect of different extraction parts from Gastrodia elata， and to provide reference for screening the anti-IS effective parts of G. elata. METHODS G. elata was extracted and separated by ethanol reflux extraction and ethyl acetate extraction. The rat model of diffuse cerebral thrombosis was induced by internal carotid artery injection of arachidonic acid （AA）； the anti-IS effect of G. elata powder， ethanol extract of G. elata， residue of ethanol extract of G. elata， ethyl acetate extract of G. elata， residue of ethyl acetate extract of G. elata， gastrodin and aspirin （positive control drug） were investigated with the content of Evans blue （EB） in the ischemic brain tissue as index. RESULTS Compared with model group， aspirin， ethanol extract of G. elata and ethyl acetate extract of G. elata could significantly decrease the content of EB in the ischemic brain tissue of model rats （P＜0.05）. G. elata powder had the tendency to reduce the content of EB in the ischemic brain tissue of model rats， without statistical significance （P＞0.05）. The residue of ethanol extract of G. elata， residue of ethyl acetate extract of G. elata and gastrodin had little effect on the content of EB in the ischemic brain tissue of model rats. CONCLUSIONS Both ethanol extract of G. elata and ethyl acetate extract of G. elata have anti-IS effects， which are stronger than that of G. elata powder.
