Effects of Morroniside on Activation of Caspase-3 in Rats with Focal Cerebral Ischemia/Reperfusion
- VernacularTitle:莫诺苷对局灶性脑缺血再灌注大鼠Caspase-3活化程度的影响
- Author:
Ying WANG
;
Dongming GAO
;
Dongming XU
;
Wen WANG
;
Houxi AI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Morroniside, ischemia/reperfusion, caspase-3, apoptosis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(9):801-802
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of morroniside on activation of caspase-3 in rats with focal cerebral ischemia/reperfusion. MethodsThe model was induced with occlusion of middle cerebral artery with suture embolus, ischemia for 30 min, and reperfusion for 72 h in rats. Vitamin E used for the positive control. The activity of caspase-3 was detected with spectrophotometry. ResultsCompared with sham group, the caspase-3 activity increased obviously in model rat. Compared with model group, Morroniside (30 mg/kg,90 mg/kg,270 mg/kg) decreased the activation of caspase-3 remarkably, which was dose-dependent (P<0.05). ConclusionMorroniside may reduce apoptosis by decreasing the activation of caspase-3 in rats.
