Molecular Biological Mechanism of Opioids Induced Hyperalgesia(review)
- VernacularTitle:阿片类药物诱导痛觉过敏的分子生物学机制
- Author:
Qiang WANG
;
Shuren LI
;
Weihua CUI
- Publication Type:Journal Article
- Keywords:
opioids, hyperalgesia, molecular biology, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(8):707-710
- CountryChina
- Language:Chinese
-
Abstract:
Opioids can activate the pro-nociceptive channel by which the sensitivity to pain has been increased, which is called opioids induced hyperalgesia (OIH). The mechanism of OIH has not been identified, but it is possibly involved in the increased activity of central glutamatergic system, changed function of opioid receptors, roles of peripheral receptors, effects of endogenous neuropeptides, decreased function of inhibitory neurotransmission system, and changed elements in signal transduction pathway, etc.
