Effects of Rehmannia and Storesin on Peripheral-type Benzodiazepine Receptors in Early Hepatic Encephalopathy Rats
- VernacularTitle:地黄苏合香合剂对早期肝性脑病大鼠脑内外周型苯二氮受体的影响
- Author:
He LIU
;
Yanyong LIU
;
Nan YANG
;
Chao JI
;
Pingping ZUO
;
Tao GONG
;
Lei LIAO
;
Xiaoming HOU
;
Zhe CAI
- Publication Type:Journal Article
- Keywords:
Rehmannia, Storesin, hepatic encephalopathy, peripheral-type benzodiazepine receptors, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(12):1122-1124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of Rehmannia and Storesin (RS) on peripheral-type benzodiazepine receptors (PBRs) in early hepatic encephalopathy (HE) rats. Methods CCl4 was used to induce the HE model. The benzodiazepine binding sites of PBRs in rats cortex were studied using the specific ligands [3] PK11195. Lactulose was used in the positive medicine group, and the treatment groups received different dosages of RS. Results The specific binding and the Bmax value of [3] PK11195 both significantly increased in the model group than in the control group (P<0.01). The specific binding decreased in the medium dosage group and the high dosage group than in the model group (P<0.05), and the Bmax value of [3] PK11195RS-H decreased in the high dosage group than in the model group (P<0.01). Conclusion Rehmannia and Storesin is effective on early HE rats by decreasing the specific binding of PBRs, which could reduce the neural injury.
